Biosystems Control Design - Diabetes

Sample exercise 1
 

1. Use PCM/Diabetes/Bergman to model the glucose response to changes in the rates of insulin and glucose infusion
   1. Estimate the parameters of a first order plus time delay model
   2. Estimate the parameters of a second order model
   3. Which model is best for modeling insulin infusion? Glucose infusion?

2. Compare your model predictions with step changes in
   1. Insulin of 1, 5, 10 mU/min
   2. Glucose infusion of 1, 2, 3 mg/dL/min
   3. Glucose infusion of 2 mg/dL/min and insulin infusion of 5 mU/L
   4. Which step changes in glucose and insulin infusion are best modeled? Why?

3. Use PCM/Diabetes/PID to tune the feedback PID controller manipulating insulin infusion using IMC-tuning rules using your best model to
   1. Track setpoint changes of +/- 20 mg/dL
   2. Reject disturbances of 25, 50, 100 g CHO

4. Use PCM/Diabetes/FF to implement a feedforward controller using the disturbance variable Ug. You should test disturbances of 25, 50, 100 g CHO
   1. Design and test a FF controller based on steady-state analysis
   2. Design and test a FF controller based on dynamic analysis